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Jose Reyes

@josei.reyesdhlhs4o8kh• Jun 28, 2022open-state

Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication - ScienceDirect

The first-line drug for HSV-1 infection is acyclovir (ACV), which is a guanine analogue that inhibits HSV replication at the level of viral DNA synthesis

However ACV cannot eliminate latent virus, which can reactivate to cause recurrent diseases even in the face of ACV treatment.

ACVr is common in immunocompromised patients, but rare in immunocompetent patients

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Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication - ScienceDirectwww.sciencedirect.com

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Jose Reyes

@josei.reyesdhlhs4o8kh• Jun 28, 2022open-state

Frontiers | Local Immune Control of Latent Herpes Simplex Virus Type 1 in Ganglia of Mice and Man | Immunology

chromatinized episomes,

The mechanisms specifying the contrasting fates of HSV-1 in neurons and epithelial cells may include differential genome silencing and chromatinization, dictated by variation in access of immune modulating viral tegument proteins to the cell body, and protection of neurons by autophagy.

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Frontiers | Local Immune Control of Latent Herpes Simplex Virus Type 1 in Ganglia of Mice and Man | Immunologywww.frontiersin.org

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 28, 2022open-state

Study Quiz 2 (página 1 de 5)

reduced pulsatile flow compared to the veins of the contralateral side

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Study Quiz 2 (página 1 de 5)miscursos.uag.mx

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 25, 2022open-state

Frontiers | Pompe disease: from pathophysiology to therapy and back again | Aging Neuroscience

(ERT) proved to be successful in reversing cardiac but not skeletal muscle abnormalities.

Pompe disease is a lysosomal storage disorder in which acid alpha-glucosidase (GAA) is deficient or absent.

Deficiency of this lysosomal enzyme results in progressive expansion of glycogen-filled lysosomes in multiple tissues, with cardiac and skeletal muscle being the most severely affected.

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Frontiers | Pompe disease: from pathophysiology to therapy and back again | Aging Neurosciencewww.frontiersin.org

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 23, 2022open-state

Popliteal fossa: Anatomy and contents | Kenhub

These include the two terminal branches of the sciatic nerve, the popliteal vessels and short saphenous vein.

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Popliteal fossa: Anatomy and contents | Kenhubwww.kenhub.com

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 20, 2022open-state

Gluteal muscles: Attachments, supply and function | Kenhub

In terms of function, the gluteal muscles act on the hip joint,

facilitate abduction and extension of the thigh but some also assist in the adduction, external rotation and internal rotation of the thigh

gluteal (buttock) region

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Gluteal muscles: Attachments, supply and function | Kenhubwww.kenhub.com

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 15, 2022open-state

Review - Assessment | Review - Assessment | PHYS Courseware | Harvard Medical School

resistance of the systemic circulation of the cardiovascular system has decreased significantly.

, in whom the resistance of the systemic circulation of the cardiovascular system decreases significantly.

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Review - Assessment | Review - Assessment | PHYS Courseware | Harvard Medical Schoolonlinelearning.hms.harvard.edu

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 15, 2022open-state

Quiz Yourself | Key Concepts | PHYS Courseware | Harvard Medical School

Compare the effect of a 50% airway narrowing in the trachea versus a 50% narrowing in one of the smaller airways.

Thus, the gas with the lowest density is most likely to be associated with laminar flow. The mixture of helium and oxygen provides the lowest density gas.

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Quiz Yourself | Key Concepts | PHYS Courseware | Harvard Medical Schoolonlinelearning.hms.harvard.edu

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 14, 2022open-state

Review - Assessment | Review - Assessment | PHYS Courseware | Harvard Medical School

As such, his heart doesn’t pump blood well, and he has expanded blood volume and elevated venous pressures.

45g of a product that equally distributes into all 3 compartments of the body

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Review - Assessment | Review - Assessment | PHYS Courseware | Harvard Medical Schoolonlinelearning.hms.harvard.edu

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Jose Reyes

@josei.reyesdhlhs4o8kh• May 9, 2022open-state

Neurocutaneous syndromes - AMBOSS

With the exception of Sturge-Weber syndrome, which is caused by a noninherited developmental anomaly of neural crest derivatives, and ataxia telangiectasia, which follows an autosomal recessive inheritance pattern, neurocutaneous syndromes disorders follow an autosomal dominant inheritance pattern, although spontaneous mutations are also possible

With the exception of Sturge-Weber syndrome, which is caused by a noninherited developmental anomaly of neural crest derivatives, and ataxia telangiectasia, which follows an autosomal recessive inheritance pattern, neurocutaneous syndromes disorders follow an autosomal dominant inheritance pattern, although spontaneous mutations are also possible

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Neurocutaneous syndromes - AMBOSSnext.amboss.com