liu
@18341350931qu54jd7_l7• Jan 28, 2023
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance | Nature Communications
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance | Nature Communicationswww.nature.com
liu
@18341350931qu54jd7_l7• Dec 4, 2022
PERK is a critical metabolic hub for immunosuppressive function in macrophages | Nature Immunology
The process of PSAT1-mediated serine synthesis, in addition to supporting mitochondrial fitness, balances the production of α-ketoglutarate (α-KG) necessary for JMJD3-dependent histone demethylation and reinforces immunosuppressive M2 activation and cell expansion
PERK is a critical metabolic hub for immunosuppressive function in macrophages | Nature Immunologywww.nature.com
liu
@18341350931qu54jd7_l7• Nov 5, 2022
Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization | Cell Death & Disease
MCF7 and T47D cells were exposed to 1 and 10 μM 4-hydroxytamoxifen,
Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization | Cell Death & Diseasewww.nature.com
liu
@18341350931qu54jd7_l7• Oct 28, 2022
RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth | PNAS
RSK2 KO mice overexpressing mock, T-betwild-type, or T-betS498E/S502E were established by bone marrow transplant assay.
RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth | PNASwww.pnas.org
liu
@18341350931qu54jd7_l7• Oct 16, 2022
Stem cell competition orchestrates skin homeostasis and ageing | Nature
To study mammalian skin ageing, we first histologically analysed mouse tail skin, which consists of well-stratified epidermal cell layers similar to human skin (
Stem cell competition orchestrates skin homeostasis and ageing | Naturewww.nature.com
liu
@18341350931qu54jd7_l7• Sep 25, 2022
Locally renewing resident synovial macrophages provide a protective barrier for the joint | Nature
orm an internal immunological barrier at the synovial lining and physically seclude the joint
局部更新的驻留滑膜巨噬细胞为关节提供保护屏障| 自然www.nature.com
liu
@18341350931qu54jd7_l7• Sep 4, 2022
能讲解一下ChIP qPCR实验的详细步骤吗? - 知乎
目的蛋白管、input样品管、阴性对照管和阳性对照管（最好设置一个）
能讲解一下ChIP qPCR实验的详细步骤吗? - 知乎www.zhihu.com
liu
@18341350931qu54jd7_l7• May 28, 2022
filezilla连接时提示“读取目录列表失败”，怎么解决？？？急！！！_百度知道
有时可能需要重启电脑才生效
filezilla连接时提示“读取目录列表失败”，怎么解决？？？急！！！_百度知道zhidao.baidu.com
liu
@18341350931qu54jd7_l7• May 28, 2022
Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids - PubMed
Treatment with either non-CSC-derived conditioned medium or exogenous lactate enhanced organoid-forming and tumor-initiating capacity of CSCs.
Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids - PubMedpubmed.ncbi.nlm.nih.gov
liu
@18341350931qu54jd7_l7• May 21, 2022
Identification of the Immune-Related Genes in Tumor Microenvironment That Associated With the Recurrence of Head and Neck Squamous Cell Carcinoma - PubMed
tumor immune estimation resource (TIMER)
Identification of the Immune-Related Genes in Tumor Microenvironment That Associated With the Recurrence of Head and Neck Squamous Cell Carcinoma - PubMedpubmed.ncbi.nlm.nih.gov