fetus has a future similar in morally relevant respects to the future lost by competent adult homicide victim

purports to derive the immorality of abortion from a deceptively simple but intuitively compelling claim

the fetus has a future similar in morally relevant respects to the future lost by a competent adult homicide victim

The aim of this paper is to provide a panoramic view of laws and policies

It shows that the plethora of convoluted laws

he mean h

he genesis of base editing (BE), as it is known, is a remarkable story of tenacity and serendipity

The CRISPR/Cas9 system consists of a single-stranded guide RNA and a Cas protein with endonuclease activity that can localize and cleave the target nucleic acid sequence (pre-spacer sequence) via Watson-Crick base pairing, resulting in DNA double-strand breaks (DSBs). In response to DSBs, the integrity of the DNA can be restored by non-homologous end joining (NHEJ) or homology-directed repair (HDR). NHEJ leads the 2 strands of the break to rejoin directly without inserting templates, which is suitable for the research and treatment of dominant genetic diseases.[2,3] However, NHEJ cannot be used in most genetic diseases because most genetic diseases require correction of a mutation at the target locus rather than disruption of the gene

Recently, a CRISPR/Cas9-based technology has been developed to precisely edit single bases of DNA without introducing DSBs in human cells (Koblan et al., 2018; Komor et al., 2016; Komor et al., 2017). The method is based on the fusion of a Cas9-D10A nickase with a cytidine deaminase

Base editor can induce specific base changes without DSBs and donor templates, which make it a convenient

The majority of human genetic diseases arise from single nucleotide changes1–2. Thus, therapeutic strategies that could allow one to correct single point mutations hold promise as powerful tools to treat genetic disorders.

"the deprivation of liberty is not arbitrary if it results from a final decision taken by a domestic judicial process; it is (a) in accordance with domestic law; and (b) in accordance with other relevant international standards set forth in the Universal Declaration of Human Rights 1948 and the relevant international instruments accepted by the States concerned" (OHCHR, 2000, Section B).

The UNHRC confirmed that Australia's mandatory immigration detention regime is arbitrary and a violation of article 9(1), which guarantees the fundamental human right of liberty.