M. canis is a zoophilic dermatophyte, which despite its name is usually acquired from infected cats. M. canis displays characteristic green fluorescence when illuminated under Wood’s lamp

Also in NF-1, axillary freckles appear at 10 years of age, while café au lait spots increase in size and number throughout childhood.

Heparin inhibits aldosterone secretion by the adrenal cortex, leading to impaired renal potassium excretion, particularly in patients with diabetes or those who are acidotic.

hypomagnesaemia impairs PTH secretion and can cause hypocalcaemia that is resistant to an increased provision of calcium.

Mutations in the LDL-receptor gene lead to the development of familial hypercholesterolaemia.

Management of homocystinuria involves pyridoxine, folic acid and B12 supplementation in combination, in an attempt to reduce homocysteine levels by methionine dietary restriction.

The gene which codes for von Willebrand factor is found on chromosome 12.

The likely diagnosis is a mixed connective tissue disease (MCTD), a diagnosis that is supported by the presence of anti-RNP antibodies.

Alpha-interferon is used in the treatment of chronic hepatitis B and C infections as well as some forms of leukaemia. Beta-interferon is used in the treatment of multiple sclerosis.